BiOmimetic fluorinated nanoProbes for multIscale Tumor detection by MRI and Advanced Raman techniques
PNRR M4C2: PRIN 2022
Acronimo: OPTIMA
Descrizione
OPTIMA project aims at developing biomimetic Fluorinated NanoParticles (FNP) as bimodal imaging probes for multiscale detection of solid tumors. Such FNP are based on a fluorine-dense core that can be detected by 19F-Magnetic Resonance Imaging (19F-MRI) and Raman spectroscopy.
Main objectives of the project will be on one side, the production of bimodal FNP with enhanced sensitivity for tumor detection by: (1) Synthesizing novel branched fluorinated molecules with a higher number of 19F atoms, increasing both MRI and Raman signal intensity, (2) applying biomimetic strategies to obtain cell membrane coated FNP with prolonged in vivo circulation lifetime and enhanced tumor homing capability. On the other side, (3) optimization of deep Raman technologies enabling the detection of FNP in tissue will be pursued.
Informazioni
- Finanziato da: Unione Europea NextGenerationEU e Ministero dell’Università e della Ricerca
- Call: PNRR: Missione 4 – Componente 2 “Dalla ricerca all’impresa” – Investimento 1.1 – Progetti di Ricerca di Rilevante Interesse Nazionale (PRIN)
- Data di inizio: 1 ottobre 2023
- Data di conclusione: 30 settembre 2025
- Responsabile scientifico ISPC: Claudia Conti
- Ente capofila: Politecnico di Milano
- Altri Enti/Istituzioni/Organizzazioni coinvolte: CNR IFN; Università degli Studi del Piemonte Orientale “Amedeo Avogadro”.
- Finanziamento: € 198.956
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